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[0098] A total of 488 patients with recurrent ME/CFS were randomized to receive either Doxycyclin (2.5-150 mg/d) or placebo
buy generic valtrex online cheap in a 2-period parallel arm trial with 48-weeks follow-up. The primary end point was ME/CFS relapse or symptom return as defined by the National Health and Nutrition Examination Survey (NHANES) 2001-2002 (1). Other primary end points such as disease duration, pharmacy online store australia disability, severity, change from baseline and clinical global impression (CGI) were monitored during treatment but assessed and evaluated with respect to safety at post-therapy visits.
Scheduling and enrollment:
Participants were enrolled between June 6, 2007 and April 18, 2007, in an international, multicentre, double-blind trial of Doxycycline and placebo. The trial was sponsored by Teva Pharmaceuticals, which produced the drug
Valtrex 1000mg $430.85 - $4.79 Per pill and manufactured all of its containers, and approved the trial protocol by ClinicalTrials.gov on June 19, 2007.
Clinical Trials
Randomization:
Participants were randomized between June 6, 2007 and April 18, 2007, between the 1st and 3rd week of treatment. Treatment eligibility was determined at baseline, on-treatment and within 2 weeks of completion Doxycycline and placebo treatment.
Analysis and Reporting:
Participants underwent evaluation by clinicians or nurses and scored using the modified Short Form-36 Hospital Health Assessment (SF-36) at baseline, and monthly 4, 8, 12 months. In
Propecia or generic finasteride addition, the SF-36 was assessed monthly at 4, 8, and 12 months by clinical investigators means of interview, scoring, and summary
Zovirax over the counter australia report, scores based on the SF-36 questionnaire were recorded.
Results:
Of the 488 patients who were randomized, 519 (94.4%) completed the 8-month study. mean score of global improvement on the SF-36 was -2.3 (SD = 7.5) at the end of treatment, an improvement from +2.4 at baseline (P<.01). There was no effect of age or sex in progression to disease relapse. The mean percentage of patients with disease activity (defined as an occurrence of at least 1 symptom/day for 2 weeks and at least 1 major symptom) and symptoms attributable to immune dysfunction (defined as an occurrence of at least 1 symptom/day for 2 weeks and at least 1 major symptom attributable to immune dysfunction for at least 60 minutes/day) increased by 5.2 and 7.1% in patients treated with Doxycycline compared placebo at each of 4 (P =.005 and 0.03, respectively) 8 months, respectively (P<.05 for 3- and 4-month changes). The mean difference in change global symptom score was 0.5 from baseline to treatment, an.
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